This revised edition of the textbook is designed for students of bachelor studies and non-medical master studies as a basic text in pathophysiology in the pertinent study programs. The exposition focuses on essential processes and their failures which are related to the supply of oxygen and nutrients, in other words, the pathophysiology of the blood circulation, respiration, blood, metabolism, digestive tract as well as regulatory mechanisms consisting of the pathophysiology of nervous and endocrine systems. In addition, it contains essential chapters on the inner environment and excretion.